The chapel is dedicated to Saint Orso, Crispin and Crispian, protectors of the guild of Shoemakers. The altarpiece, built in the early sixteenth century, is the work of Martin Spanzotti, with the collaboration of Defendente Ferrari. In the center, the Virgin is portrayed while breast feeding. On the sides, after thebreakdown of the seventeenth century altarpiece, eighteen painted panels depicting the life and martyrdom of the holy holders of the 0chapel were placed in stucco frames.